學經歷

學歷

2000/3

Ph. D. (Dr. of Agriculture) from Graduate School of Science and Technology, Niigata University (Niigata, Japan).

1996/3

Master's degree from Graduate School of Agriculture, Niigata University (Niigata, Japan).

1994/3

Graduated from Department of Agricultural Chemistry, Niigata University (Niigata, Japan).

現職

2019/2 -present

Assistant Professor, Institute of Molecular Medicine, National Cheng-Kung University, Tainan, Taiwan.

經歷

2013/5 -2019/1

Project Assistant Professor, Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University.

2007/11-2013/4

Assistant Professor, Young Researchers Empowerment Center, Shinshu University.

2005/6-2007/10

Assistant Professor, Division of Gene Research Center, Human and Environment Science Research Center, Shinshu University.

2002/8 -2005/5

Postdoctoral research fellow of Department of Biology, Tokyo Metropolitan University.

2002/4 -2002/7

Postdoctoral research fellow of Kyowa Hakko Co., Ltd., detached to Department of Biology, Tokyo Metropolitan University.

2000/4 -2002/3

Postdoctoral research fellow of Bio-oriented Technology Research Advancement Institution, detached to Department of Agricultural Chemistry, Shizuoka University.

專長/研究興趣

興趣

1) Prevention for Enterohemorrhagic E. coli infection. Screening of chemical inhibitor for EHEC infection, and inhibition of Shiga toxin production by anti-phage defense system. 

2) Synthetic biology and biotechnology. We developed an in vivo target cloning system for long DNA fragment which is too long for PCR amplification. We demonstrate to clone 50-100kb fragment from gram negative bacteria. We are expanding the method to variety of bacteria. In addition, we are developing biotechnological tools by using novel negative selection markers.

3) Bacterial genomic evolution. We found some restriction-modification systems are involved in genomic evolution in uropathogenic E. coli. Novel restriction enzymes were identified and characterized. Then, we are investigating the association between the gene and the bacterial genomic evolution in the pathogenic E. coli.

方向

Bacteria is a simple organism, and E. coli is one of the best studied bacteria. But it's still providing a novel interesting phenomena and findings. Studying the mechanisms on molecular level led us to know the bacteria more and more, then finally I want to understand everything in a cell.

Educations / Professional Experience

Educations

2000/3

Ph. D. (Dr. of Agriculture) from Graduate School of Science and Technology, Niigata University (Niigata, Japan).

1996/3

Master's degree from Graduate School of Agriculture, Niigata University (Niigata, Japan).

1994/3

Graduated from Department of Agricultural Chemistry, Niigata University (Niigata, Japan).

Current Position

2019/2 -

Assistant Professor, Institute of Molecular Medicine, National Cheng-Kung University, Tainan, Taiwan.

Professional Experience

2013/5 - 2019/1

Project Assistant Professor, Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University.

2007/11 - 2013/4

Assistant Professor, Young Researchers Empowerment Center, Shinshu University.

2005/6 - 2007/10

Assistant Professor, Division of Gene Research Center, Human and Environment Science Research Center, Shinshu University.

2002/8 - 2005/5

Postdoctoral research fellow of Department of Biology, Tokyo Metropolitan University.

2002/4 - 2002/7

Postdoctoral research fellow of Kyowa Hakko Co., Ltd., detached to Department of Biology, Tokyo Metropolitan University.

2000/4 - 2002/3

Postdoctoral research fellow of Bio-oriented Technology Research Advancement Institution, detached to Department of Agricultural Chemistry, Shizuoka University.

Expertise /Research Interests

Research

Interests

1) Prevention for Enterohemorrhagic E. coli infection. Screening of chemical inhibitor for EHEC infection, and inhibition of Shiga toxin production by anti-phage defense system. 

2) Synthetic biology and biotechnology. We developed an in vivo target cloning system for long DNA fragment which is too long for PCR amplification. We demonstrate to clone 50-100kb fragment from gram negative bacteria. We are expanding the method to variety of bacteria. In addition, we are developing biotechnological tools by using novel negative selection markers.

3) Bacterial genomic evolution. We found some restriction-modification systems are involved in genomic evolution in uropathogenic E. coli. Novel restriction enzymes were identified and characterized. Then, we are investigating the association between the gene and the bacterial genomic evolution in the pathogenic E. coli.

Research

Directions

Bacteria is a simple organism, and E. coli is one of the best studied bacteria. But it's still providing a novel interesting phenomena and findings. Studying the mechanisms on molecular level led us to know the bacteria more and more, then finally I want to understand everything in a cell.

目前實驗室成員：

碩士生

M2: 洪昀昇、Kamryn Escalant

M1: 陳琬菁、林佳怡、吳振義

大學部: 龔宇傑

畢業學生：

碩士班

2014

謝堉文

2017

馬翊棻

2019

Trayee Dhar

2020

楊秉錩、Oiti Ka

2021

馮曉誠

Current member：

Degree students

M2: 洪昀昇、Kamryn Escalant

M1: 陳琬菁、林佳怡、吳振義

大學部: 龔宇傑

Alumni：

Master’s degree

2014

謝堉文

2017

馬翊棻

2019

Trayee Dhar

2020

楊秉錩、Oiti Ka

2021

馮曉誠