張惠華 Louis W. Chang

Louis W.Chang

Louis W. Chang

E-mail：

TEL：06-2353535 ext 4226

FAX：06-2095845

　

Educations / Professional Experience

　
Educations 1987-1988

In-vitro Neuroscience/Biochem. Neurotoxicology(Professors Jean deVellis  and Anthony Verity),U.C.L.A ‑ Brain Research Institute Los Angeles,California
　

1969-1972

Ph.D., Pathology  with Minor in Neuroscience,University of Wisconsin-Madison School of Medicine Madison, Wisconsin
　

1968-1969

Ph.D. Candidate,Anatomy (CompletedQualifying Exam.),Tufts University School of Medicine,Boston, Massachusetts
　

1967‑1969

Neurocytology(Prof. Sanford Palay)、Medical Pathology(Prof. Samuel Farber),Harvard Medical School,Boston, Massachusetts
　

1966-1969

M.S., Anatomy and Histochemistry Tufts University,School of Medicine,Boston, Massachusetts
　

1962-1966

B.A., Chemistry and Biology University of Massachusetts  Amherst, Massachusetts
　 　

　
Current Appointments

2004 - present

Adjunct Professor, Department of Occupational Health and Safety, Chung-Shan Medical        University, Taichung, Taiwan
　

2000 - present

Emeritus Professor of Pathology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
　

1999 - present

Founding Director and Investigator, Div. of Environmental Health & Occupational Medicine, National Health Research Institutes, Taiwan
　
　
Former Appointments

1972/7-1973

Instructor in Pathology, University of Wisconsin
　

1972/7-1976

Director, Histopathology and Histochemistry Laboratories, University of Wisconsin
　

1973/7-1976/12

Assistant Professor of Pathology, Univ. of Wisconsin
　

1977/1-1978/9

Experimental Neuropathologist, Pathology Services, National Center for Toxicological Research, Jefferson, Arkansas
　

1978/10-1981

Guest Scientist, Pathology Services, National Center for Toxicological Research, Jefferson, Arkansas
　

1977/1-1980

Associate Professor of Pathology, University of Arkansas for Medical Sciences, and National Center for Toxicological Research
　

1980-2000

Professor of Pathology and Graduate Director of Experimental Pathology, University of Arkansas for Medical Sciences
　

1983-2000

Professor of Pharmacology & Toxicology, Univ. of Arkansas for Medical Sciences
　

1988‑1991

Acting Director, Division of Toxicology, Dept. of Pharmacology & Toxicology, University of Arkansas for Medical Sciences
　

1988‑1991

Director, Interdisciplinary Toxicology Program, University of Arkansas for Medical Sciences
　

1997-1999

Coordinator, Pathophysiology Ph.D. Program, Univ. of Arkansas for Medical Sciences
　

1999–2004

Director& Investigator, Div. of Environmental Health & Occupational Medicine (DEHOM), National Health Research Institutes (NHRI), Taiwan
　

1990- 1999

Visiting Professor, The Chinese Academy of Medicine, Beijing, China
　

1990-1999

Visiting Professor, Institute of Occupational & Preventive Medicine, Beijing, China
　

1990-1999

Visiting Professor, Industrial University, Xian, China

　

Expertise /Research Interests

　

Environmental Health & Occupational Medicine

Toxicological Risk Assessment/Regulatory Guideline Development

Neuroscience/Neurotoxicology/Neuropathology

Heavy Metal Toxicology/Persistent Organic Pollutants (POPs) Research

Developmental & Reproductive Toxicology/Endocrine Disrupters Research

Histochemistry/Microanatomy/Ultrastructural Cytology

Cellular and Molecular Biology/Toxicogenomics
　 　

Honors & Awards
　

  • "Golden Forceps Award," first runner‑up for the best contribution of the year in histologicaltechniques. 

  • AFIP 10th Annual Symposium on Histopathological Techniques.  Silver Springs, Maryland, 1974.

  •  "Golden Forceps Award," recipient for the best contribution of the year in histological techniques. 

  • First National Society of Histotechnology Symposium, Silver Springs, Maryland, 1975.

  • Who’s Who in Wisconsin, 1975

  • American Men and Women in Science, 1976

  • Outstanding Young Men of America, 1979

  • Who’s Who in the South and Southwest, 1982

  • Who’s Who in Frontier of Science and Technology, 1983

  • Personality of the South, 1974

  • Distinguished Leadership and Service Award (The American-Chinese   Toxicology Society), 1987/89

  • Who’s Who in Science and Engineering, 1993

  • Who’s Who Among Asian Americans, 1993

  • Who’s Who in the World, 1994

  • International Man of the Year on Medicine and Education, 1994/95

  • Principles of Neurotoxicology, edited by Dr. Chang was selected as one of the 250 Best Health Science

  • Books of the year, 1994/1995

  • The 20th Century Award of Achievement on Toxicology and Medicine, 1995

  • Who’s Who in American Education, 1995

  • The Most Admired Men and Women of the Year, 1995

  • International Directory of Distinguished Leadership, 1995

  • 2000 Notable American Men, 1995

  • 5000 Personalities of the World for Outstanding Achievement, 1996

  • Who’s Who in Sciences and Engineering, 1996/1997

  • 2000 Outstanding people of the 20th Century, 1997/98

  • Golden Scroll of Excellence in Environmental Health and Toxicology, 1997

  • Who’s Who in Medicine and Healthcare, 1999

  • International Scientist of the Year, 2003
　
Books and Book Chapters (1994-2010)
　
  1. Lin, P., Yang R S.H., Yang, C.S., Lin, C.H., Chang, L,W. Toxicology & Safety Evaluation of Quantum Dots, In: Semiconductor Nanomaterials for Life Sciences, Vol. 6: Quantum Dots. (C. Kumar, editor), Wiley Publisher, (in press), 2010.
  2. Chang, L.W. Preface. In: Toxicology of Metals, pp. 1198, Lewis Publishers, CRC Press, Inc., Boca Raton, FL., 1996.
  3. Chang, L.W. Toxico-neurology and neuropathology induced by metals. In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Inc., Boca Raton, FL., pp. 511-536, 1996.
  4. Chang, L.W. An introduction to bioresponses and reactivities of metals. In: Toxicology of Metals, (L.W. Chang, ed.), Lewis Publishers, CRC Press, Boca Raton, FL., pp. 111-112, 1996.
  5. Chang, L.W. An introduction to metal effects on other organ systems. In: Toxicology of Metals, (L.W. Chang, ed.) Lewis Publishers, CRC Press, Boca Raton, Fl., pp. 885-886, 1996.
  6. Chang, L.W., and Dyer, R. (editors). Handbook of Neurotoxicology, Marcel Dekker, Inc., N.Y. (1103 pp.), 1995.
  7. Chang, L.W., and Verity, M.A. Mercury Neurotoxicity: Effects & Mechanisms. In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc. N.Y., pp. 31-60, 1995.
  8. Chang, L.W. Neurotoxicology of organotin and organolead compounds. In: Handbook of Neurotoxicology (L.W. Chang and R. Dyer, eds.), Marcel Dekker, Inc., N.Y., pp. 171-212, 1995.
  9. Chang, L.W., and Slikker, W. Jr. (editors). Neurotoxicology: Approaches and Methods. Academic Press, Inc., CA, (pp. 824), 1995.
  10. Chang, L.W. Selected histopathological and histochemical methods for neurotoxicity assessment. In: Neurotoxicology: Approaches and Methods (L.W. Chang and W. Slikker, Jr., eds.), Academic Press, Inc., CA, pp. 5-26, 1995.
  11. Fan, A.M., and Chang, L.W. (editors). Toxicology and Risk Assessment. pp. 859, Marcel Dekker, Inc., N.Y., 1995.
  12. Chang, L.W. (editor). Principles of Neurotoxicology, Marcel Dekker, Inc., N.Y. (824 pp.),1994.
  13. Chowdhury, P., Montague, D.C., Rayford, P., Chang, L.W., and Lyn-Cook,B. Nicotine alters pancreatic gene (Ha-ras) expression and induce point mutation and exocrine pancreatic injury. In: Proc. XVI International Cancer Congress, New Delhi, India. Monduzzi Editoire, Bologna Publisher (Italy), pp.369-373, 1994.
    　
　
Invited Lectures, Seminars and Symposia (2007-2009)
　

  1. Chang, L.W., Lee, H.L., Lin, P. Enhancement of NNK metabolism by arsenic as the mechanism for increased cigarette smoke lungcarcinogenicity by arsenic. Soc. Of Toxicology Meeting, Baltimore, MD. March 15-19, 2009.

  2. Chang, L.W., Liao, W.T., Yu, H.S., and Lin, P. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. 7th ERS Lung Science Conference, Estoril, Portugal, March 27-29, 2009.

  3. Chang, L.W. and Lin, P. Enhancement of cigarette smoke-induced lung carcinogenesis by arsenic. Lung Research Group, University of California-Davis, April 16-17, 2009.

  4. Chang, L.W., Liao, W.T., Yu, H.S., Lin, P. Interaction of cigarette smoke component NNK and arsenic in enhancement of lung carcinogenic risk. AACR 100th Annual Meeting, Denver, CO. (abstract #1217), April 18-22, 2009.

  5. Chang, L.W. Enhancement of cigarette-induced lung carcinogenesis by arsenic. Institute of Molecular Medicine, National Cheng-Kung University, June 12, 2009

  6. Chang, L.W. Synergistic interaction of arsenic and cigarette smoke components, BaP and NNK, in enhancement of carcinogenesis. China Medical University, Taiwan. March, 2008.

  7. Lin P. and Chang, L.W. Potential of tt-DDE in cooking oil fumes in the induction of lung carcinogenesis. Department of Occupational Medicine, National Taiwan University, Taiwan. May, 2008.

  8. Liao, W.T. and Chang, L.W. Enhancement of arsenic on centrosome abnormality in NNK-treated or p53 compromised human lung bronchiolar epithelial cells. Div. of Environmental Health & Occupational Medicine, National Health Research Institutes. June, 2008.

  9. Chang, L.W., Lee H.L., Wu, J.P., Lin, P. Synergistic enhancement of carcinogenic risk via interaction of arsenic and cigarette smoke components. 14th International Charles Heidelberger Symposium on Cancer Research, Urumqi, Xinjiang, China. September 19-25, 2008.

  10. Chang, LW. Enhancement of NNK and BaP metabolisms by arsenic:interaction of cigarette smoke components and arsenic in carcinogenesis. NHRI P.I. Retreat Conference. Long-Tan, Taiwan, September, 2008.

  11. Chang, L.W. Interrelationship between p53, NNK, and arsenic inenhancement of lung carcinogenic risk. International Arsenic Symposium, Kaohsiung Medical University, December 1, 2008.

  12. Chang, L.W. Arsenic Research Program at the National Health ResearchInstitutes. Div. of Environmental Health & Occupational Medicine, NHRI,December 11-12, 2008.

  13. Lee, H.L. and Chang, L.W. Alteration of NNK metabolism in arsenic / cigarette smoke interaction in the enhancement of lung cancer risk. Academia Sinica, Taiwan. March, 2007.

  14. Chang, L.W. Mercury and cardiovascular disease. In: Heavy Metal Toxicology Symposium. International Academy of Oral Medicine and Toxicology (IAOMT) Annual Meeting, Las Vegas, September, 2007

  15. Chang, L.W. Safety evaluation on the nano-material Quantum Dot 705: a pharmacokinetic and pathological study. Department of Environmental Health & Occupational Safety, National Yang Ming University, Taiwan. October, 2007.