研究成果 ( Publications)

A.期刊論文 Refereed Papers (2000~)

1. Chao HC, Wu LW and Lin JY*. (2024 May). Ilex kudingcha’s phenolic-rich fraction inhibits murine squamous cell carcinoma (SCC7) through restoring adaptive immunity and Th1-polarized immune balance in vitro and in vivo. S Afr J Bot 168: 209-220.
2.  Jia-Horung Hung , Ping-Hsing Tsai , Wilson Jr F Aala , Chao-Chung Chen , Shih-Hwa Chiou , Tak-Wah Wong , Kuen-Jer Tsai , Sheng-Min Hsu , Li-Wha Wu. (2024 Feb).TIMP3/Wnt axis regulates gliosis of Müller glia.   17;1870(4):167087.
3. Hung JH, Tsai PH, Aala WJF, Chen CC, Chiou SH, Wong TW, Tsai KJ, Hsu SM*, Wu LW*. (2024 Feb). TIMP3/Wnt axis regulates gliosis of Müller glia. Biochim Biophys Acta Mol Basis Dis. 1870(4):167087.
4. Chen JW, Shih CJ, Wu LW*, Wu YC, Chiang WF, Chen YL, Wu JH*. (2023 Feb). Phocaeicola oris sp. nov., an anaerobic bacterium isolated from the saliva of a patient with oral squamous cell carcinoma and emended description of Bacteroides kribbi. Int J Syst Evol Microbiol. 73(2).
5. Kuo YZ, Kang YR, Chang WL, Sim LCL, Hsieh TC, Chang CH, Wang YC, Tsai CJ, Huang LC, Tsai ST*, and Wu LW*.  (2022 Oct) YAP1 acts as a negative regulator of protumor TAZ expression in esophageal squamous cell carcinoma. Cell Oncol. 45(5):893-909.
6. Chen YL*, Huang KC, Wu JH, Liu T, Chen JW, Xie JY, Chen MY, Wu LW,  Tung CL*. (2022 Aug) Microbiome dysbiosis inhibits carcinogen-induced murine oral tumorigenesis. J Cancer 13(10):3051-3060.
7. Yang, SF, Su YC, MD, Lim CC, MD, Huang JY, Hsu SM, Wu LW,  Chang YS, and Hung JH*. (2022 Jun) Risk of dialysis in patients receiving intravitreal anti-vascular endothelial growth factor treatment: A population-based cohort study. Aging 14(12):5116-5130.
8. Chen JW, Wu JH*, Chiang WF, Chen YL, Wu WS, and Wu LW*. (2021 Sept) Taxonomic and functional dysregulation in salivary icrobiomes during oral carcinogenesis. Front Cell Infect Microbiol 11:663068.
9. Chiu SF, Ho CH, Chen YC, Wu LW, Chen YL, Wu JH, Wu WS, Hung HK, and Chiang WF*. (2021 May) Epidemiology profile and outcomes of oral potentially malignant disorders among different geographic regions of Taiwan: A retrospective observational nationwide population database study. J Med Sci 41 (6):286-294.
10. Chen MY, Chen JW, Wu LW, Huang KC, Chen JY, Wu WS, Chiang WF, Shih CJ, Tsai KN, Hsieh WT, Ho YH, Wong TW, Wu JH*, Chen YL*. (2021 Apr) Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes. J Dent Res 100(4):397-405.
11. Chiu SF, Ho CH, Chen YC, Wu LW, Chen YL, Wu JH, Wu WS, Hung HK, Chiang WF*. (2021 Mar) Malignant transformation of oral potentially malignant disorders in Taiwan: an observational nationwide population database study. Medicine (Baltimore) 100(9):e24934.
12. Lu SW, Pan HC, Hsu YH, Chang KC, Wu LW, Chen WY, and Chang MS*. (2020 Sep) IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nat Commun 11(1):4611.
13. Cheng HM, Kuo YZ, Chang CY, Chang CH, Fang WY, Chang CN, Pan SC, Lin  JY*, and Wu LW*.  (2020 Jun) The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by deferentially inhibiting cytokine expression J Ethnopharmacol 255:112760.
14. Fang WY, Kuo YZ, Chang JY, Hsiao JR, Kao, HY, Tsai ST*, and Wu LW*. (2020 May) The tumor suppressor TGFBR3 blocks lymph node metastasis in head and neck cancer. Cancers. 12(6):E1375.
15. Huang YH, Chang CY, Kuo YZ, Fang WY, Kao HY, Tsai ST*, Wu LW*.  (2019 Sept) Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer. Cancer Sci. 110(9):2783-2793
16. Pan SC, Li CY, Kuo CY, Kuo YZ, Fang WY, Huang YH, Hsieh TC, Kao HY, Kuo Y, Kang YR, Tsai WC, Tsai ST, Wu LW. (2018 Apr) The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing. Sci Rep. 8(1):5458. doi: 10.1038/s41598-018-23697-5.
17. Pan SC, Lee CH, Chen CL, Fang WY, Wu LW. (2018 Feb) Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion. Ann Plast Surg. 80(2S Suppl 1):S79-S83.
18. Chen SH, Wong TW, Lee CH, Chen CL, Wu LW, Pan SC*. (2018 Feb) Predominance of CD14+ Cells in Burn Blister Fluids. Ann Plast Surg. 80(2S Suppl 1):S70-S74.
19. Kuo YZ, Fang WY, Huang CC, Tsai ST*, Wang YC, Yang CL, Wu LW*. (2017 Feb) Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer. Oncotarget. 8(9):15563-15583.
20. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW*, Wang YC*. (2017 May) Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res. 23(9):2335-2345,
21. Hsu YH, Yang YY, Huwang MH, Weng YH, Jou IM, Wu PT, Lin TY, Wu LW, Chang MS. (2017 Apr) Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. PLoS One. 12(4):e0175802.
22. Cheng CW, Hsiao JR, Fan CC, Lo YK, Tzen CY, Wu LW, Fang WY, Cheng AJ, Chen CH, Chang IS, Jiang SS, Chang JY, Lee AY. (2016 May) Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. Mol Carcinog. 55(5):499-513.
23. Hsu YH, Wu CY, Hsing CH, Lai WT, Wu LW, Chang MS.(2015 Oct) Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models. PLoS One 10(10).e0139871
24. Fang WY, Chen YW, Hsiao JR, Liu CS, Kuo YZ, Wang YC, Chang KC, Tsai ST*, Chang MZ, Lin SH, and Wu LW*. (2015 Sept). Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production. Oncotarget. 6(29):28401-24 (SCI).
25. Taniguchi K, Wu LW, Grivennikov SI, Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS,Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Jessica Zucman-Rossi J, Guan KL, Karin M. (2015 Mar). A gp130-Src-YAP module links intestinal injury and inflammation to epithelial regeneration. Nature 519:57-62.
26. Wu JM, Hsueh YC, Ch’ang HU, Luo CY, Wu LW, Nakauchi H, Hsieh PC. (2015 Feb)  Circulating cells contribute to cardiomyocyte regeneration after injury. Circ Res. 116(4):633-41.
27. Wang K, Kim M., Caro1 GD, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Wu LW, Taniguchi K., Feng Y, Fearon E, Grivennikov SI, and Karin M. (2014 Dec) Inteleukin-17 A receptor A signals in transformed enterocytes to promote early colorectal tumorigenesis.Immunity 41(6):1052-63.
28. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M.(2014 Sept) Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 111(38): 13870-5.
29. Kuo YZ, Tai YH, Lo HI, Chen YL, Cheng HC, Fang WY, Lin SH, Yang CL, Tsai ST*, Wu LW*. (2014 Apr) MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer. Oral Diseases. 20:e65-75.
30. Su MT, Lin SH, Chen YC, Wu LW, Kuo PL. (2013 Jun) Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy. Reproduction. 146(1):63-73 (SCI).
31. Huang YH, Wu MP, Pan SC, Su WC, Chen YW, Wu LW . (2013 Jan) STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production. Angiogenesis. 16(1):207-22.
32. Pan SC, Wu LW , Chen CL, Shieh SJ, and Chiu YC. (2012-Sep) Angiogenin expression in burn blister fluid: Implications for its role in burn wound neovascularization. Wound Repair and Regeneration. 20(5):731-9 (SCI).
33. Yeh CH, Tsai SH, Wu LW*, and Lin YC*. (2011 Aug) Using co-culture microsystem for cell migration under fluid shear stress. Lab Chip. 11:2583-90.
34. Tsai WC, Lin YC, Tsai ST, Shen WH, Chao TL, Lee SL, and Wu LW. (2011 Apr) Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma. Oral Diseases. 17:283-290.
35. Chen JY, Tang YA, Huang SM, Juan HF, Wu LW, Sun YC, Wang SC, Wu KW, Balraj G, Chang TT, Li WS, Cheng HC, and Wang YC. (2011 Jan) A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis. Cancer Research. 71:473-83.
36. Kao YC, Wu LW, Shi CS, Chu CH, Huang CW, Kuo CP, Sheu HM, Shi GY, and Wu HL*. (2010 Oct) Down-regulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition. Molecular and Cellular Biology. 30:4767-85.
37. Tsai ST, Chien IH, Shen WH, Kuo YZ, Jin YT, Wong TY, Hsiao JR, Wang HP, Shih NY, Wu LW*. (2010 Jun) ENO1, a potentialprognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction.  European Journal of Cancer. 46:1712-23.
38. Pan SC, Wu LW *, Chen CL, Shieh SJ, Chiu HY*. (2010 May-Jun) Deep partial thickness burn blister fluid promotes neovascularization in the early stage of burn wound healing. Wound Repair Regeneration. 18:311-8.
39. He MF, Huang YH, Wu LW*, Ge W, Shaw PC, and But PPH*.  (2010 Jan) Triptolide functions as a potent angiogenesis inhibitor. International Journal of Cancer. 126:266-278.
40. Sun YN, Wang YY, Chang SC, Wu LW and Tsai ST.  (2010 Jan)  Color-based tissue segmentation for the automated estimation of oral cancer parameters.  Microscopy Research and Technique. 73:5-13.
41. Yang JC, Deng CF, Wu HC, Chuang HC, Tsai TF, Hsu HY, Huang WY, Wu LW, and Su IJ. (2009 Jun) Enhanced Expression of Vascular Endothelial Growth Factor-A in Ground Glass Hepatocytes and Its Implication for Hepatitis B Virus-related Hepatocarcinogenesis. Hepatology. 49:1962-1971.
42. Lo IC, Lin TM, Chou LH, Liu SL, Wu LW, Shi GY, Wu HL, Jiang MJ. (2009 Mar) Ets-1 mediates platelet-derived growth factor-bb-induced thrombomodulin expression in human vascular smooth muscle cells. Cardiovascular Research 81(4):771-779.
43. He MF, Liu L, Ge W, Shaw PC, Jiang R, Wu LW, and But PPH. (2009 Jan) Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. Journal of Ethnopharmacology. 121:61-8.
44. Chen YH, Huang YH, Wu HL, Wu MP, Kuo YZ, Chang WT, Lu KC and Wu LW. (2008 Nov) Angiostatin K1-3 induces E-selectin via AP1 and Ets1: a mediator for anti-angiogenic action of K1-3. Journal of Thrombosis and Haemostasis. 6: 1953-1961.
45. Wu MP, Young MJ, Tzeng CC, Tzeng CR, Huang KF, Wu LW * and Chou CY*. (2008 Jun) A novel role of thrombospondin-1 in cervical carcinogenesis: Inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer. Carcinogenesis. 29: 1115-23.
46. Hu HT, Huang YH, Chang YA, Lee CK, Jiang MJ, and Wu LW. (2008 Sept)  Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. J. Invest. Dermatol. 128:2325-33.
47. Wu LW, Chiang YM, Chuang HC, Lo CP, Yang KY, Wang SY, Shyur LF. (2007 Jun) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. Planta Medica. 73:655-61.
48. Tsai WC, Tsai ST, Jin YT, and Wu LW. (2006 Aug) Cyclooxygenase 2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. Mol Cancer Res. 4:539-547.
49. Chen YH, Wu HL, Li C, Huang YH, Chiang CW, Wu MP, Wu LW. (2006 Apr) Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5: Involvement of p53, FasL, AKT and mRNA deregulation. Thromb Haemost. 95:668-77.
50. Tsai ST, Yang KY, Jin YT, Lin YC, Chang MT, and Wu LW. (2006 Apr) Amphiregulin as a Tumor Promoter for Oral Squamous Cell Carcinoma: Involvement of Cyclooxygenase 2.  Oral Oncol. 42: 381-390.
51. Lau KHW, Wu LW, Sheng M, Amoui M, Suhr SM and Baylink DJ. (2006 Apr) An Osteoclastic Protein-Tyrosine Phosphatase is a Potential Positive Regulator of the c-Src Protein-Tyrosine Kinase Activity, a Mediator of Osteoclast Activity. J Cell Biochem. 97:940-55.
52. Tsai ST, Jin YT, Tsai WC, Wang ST, Lin YC, Chang MT, and Wu LW. (2005 Apr) S100A2, a potential marker for early recurrence in early-stage oral cancer. Oral Oncol. 41:349-357.
53. Wu LW, Chiang YM, Chang HC, Wang SY, Yang GW, Chen YH, Lai LY and Shyur LF. (2004 Nov). Polyacetylenes function as anti-angiogenic agents. Pharma. Res.  21:2112-2119.
54. Lien WH, Chen CK, Lai LY, Chen YH, Wu MP, and Wu LW. (2004 Aug)  Participation of cyclin D1 deregulation in TNP-470- mediated cytostatic effect: Involvement of senescence. Biochem. Pharmacol. 68:729-738.
55. Tsai WC, Tsai ST, Ko JY, Jin YT, Li C, Huang W, Young KC, Lai MD, Liu HS, Wu LW. (2004 Apr)  The mRNA profile of genes in betel-quid chewing oral cancer patients. Oral Oncol. 40:418-426.
56. Wu MP, Tzeng CC, Wu LW, Huang KF, Chou CY. (2004 Jan-Feb) The thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis. Cancer J. 10:27-32.
57. Lin YC, Li M, Fan CS, Wu LW. (2003 Nov) A microchip for electroporation of primary endothelial cells. Sensors and Actuators- A Phy. 108:12-19.
58. Chen YH, Wu HL, Chen CK, Huang YH, Yang BC, Wu LW. (2003 Oct) Angiostatin antagonizes the action of VEGF-A in human endothelial cells via distinct pathways. Biochem Biophys Res Comm. 310: 804-810.
59. Chen YJ, Jin YT, Shieh DB, Tsai ST, and Wu LW. (2002 Oct) Molecular characterization of angiogenic properties in oral squamous cell carcinoma cells.  Oral Oncology. 38:699–705.
60. Guo YL, Chang HC, Tsai JH, Huang JC, Li C, Young KC, Wu LW, Lai MD, Liu HS, Huang W. (2002 Aug) Two UVC-induced stress response pathways in HeLa cells identified by cDNA microarray. Environ Mol Mutagen. 40:122-128.
61. Jih YJ, Lien WH, Tsai WC, Yang GW, Li C, and Wu LW. (2001 Dec) Distinct regulation of genes by bFGF and VEGF in endothelial cells. Angiogenesis. 4: 313-21.
62. Chen CC, Shieh B, Peck K, Tsai TS, Huang CH, Liau YE, Liou JT, Su IJ, Chow NH, Tzeng CC, Chiu WH, Jin YT, Wu LW, Huang W, Young KC, Lai MD, Liu HS, and Li C. (2001 Mar-Apr) Microarray profiling of gene expression patterns in bladder tumor cells treated with genistein. J. Biomed. Sci. 8:214-222.
63. Guo DQ, Wu LW, Dunbar JD, Ozes ON, Mayo LD, Kessler KM, Gustin JA, Baerwald MR, Jaffe EA, Warren RS, and Donner DB. (2000 Apr) Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem. 275: 11216-11221.
64. Wu LW, Mayo LD, Dunbar JD, Kessler KM, Oses ON, Warren RS, and Donner DB. (2000 Mar) VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. J. Biol. Chem. 275:6059-6062.
65. Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA, Wang D, Warren RS, and Donner DB. (2000 Feb) Utilization of distinct signaling pathways by receptors for VEGF and other mitogens in the induction of endothelial cell proliferation. J Biol Chem. 275:5096-5103.

B. 研討會論文 Conference papers

a. 國際會議

1. Sim LCL, Kuo YZ, Tsai ST*, and Wu LW*. The cell- and non-cell autonomous actions of UCA1 dysregulation in hypopharyngeal cancer. The 111th Annual Meeting for American Association for Cancer Research, Orlando, FL, USA, 2023 Apr 14-19, 2023.
2. Biswas PK and Wu LW*. A regulatory role of UTP14A expression on lipid metabolism and EMT process in oral cancer. 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology, Taipei, Nov 7-11, 2022.
3. Wu LW*. The context-dependent role of deregulated DCBLD1 expression in esophageal cancer. The 2nd Asia Pacific Workshop and Conferences on Molecular Medicine, Chonburi, Thailand, August 24-25, 2022 (oral presentation).
4. Fang WY, WY, Tsai ST, Wu JH, and Wu LW. The multi-faceted role of TGFBR3 deregulation in oral cancer progression.International Conference on Cancer Biology and Anti-Cancer Therapies. Jun 24-25, 2019, Singapore, Singapore.
5. Hung HH, Wu LW* and Tsai ST*. The role and action mechanism of cortactin involved in head and neck cancer metastasis to lymph nodes. The 3rd World Congress on Cell Science and Molecular Biology (Cell Science-2019), May 13-14, 2019, Kuala Lumpur, Malaysia.
6. Lin IH, Wu LW*, and Tsai ST*. The action mechanism whereby oral cancer-associated microRNAs mediate oral carcinogenesis. The 3rd World Congress on Cell Science and Molecular Biology (Cell Science-2019), May 13-14, 2019, Kuala Lumpur, Malaysia.
7. Huang YH, Tsai ST, Wu LW*. The differential role of DCBLD family in esophageal carcinogenesis. The 3rd World Congress on Cell Science and Molecular Biology (Cell Science-2019), May 13-14, 2019, Kuala Lumpur, Malaysia.
8. Wu LW*, Chang CY, Huang YH, Kuo YZ, and Tsai ST*. Cell autonomous and non-autonomous actions of CCL22 in oral carcinogenesis. The 111th Annual Meeting for American Association for Cancer Research, Mar 29-Apr 3, 2019. Atlanta, GA, USA.Wu LW*, Lin IH, Chiang WF, Wu JH, Wu WS, and Chen YL. Differential regulation of microRNAs by oral microbes associated with oral verrucous hyperplasia. 6th World Congress on Targeting Microbiota Towards Clinical Revolution, Oct 28-30, 2018, Porto, Portugal.
9. Huang YH, Kuo YZ, Chang CY, Fang WY, Tsai ST*, and Wu LW*. Epithelial S100A2 expression reduced upper aerodigestive track carcinogenesis by immunomodulation. The 110th Annual Meeting for American Association for Cancer Research, April 14-18, 2018. Chicago, IL, USA.
10. Fang WY, Chen YW, Kuo YZ, Hsiao JR, Liu CS, Tsai ST* and Wu LW*. Up-regulated S100A9 in stroma functions as a recurrence marker for early-stage oral cancer patients through increased tumor invasiveness, angiogenesis, macrophage recruitment and IL-6 expression. International Congress of Immunology, Aug 21-26, 2016. Melbourne, Australia.
11. Wu LW, Fang WY, Chen YW, Hsiao JR, Liu CS, Chang KC, Kuo YZ, and Tsai ST*. S100A9, an early oral cancer recurrence marker, exerts a pro-tumor effect through myeloid cell recruitment and IL-6 production. Asian Oncology Summit. May 10-12, 2015, Shanghai, China.
12. Chen YW, Fang WY, Hsiao JR, Kuo YZ, Lin SH, Chang MZ, Tsai ST and Wu LW*. High stromal S100A9 expression serves an early oral cancer recurrence marker possibly through enhancing cancer cell invasiveness, angiogenesis, and differentially recruiting infiltrating immune cells. The 105th Annual Meeting for American Association for Cancer Research, April 5-9, 2014. San Diego, USA.
13. Fang WY, Hsiao JR, Chang CY, Tsai ST, and Wu LW*. Functional implication of TGFBR3 dysregulation and its clinical application in oral cancer. The 104th Annual Meeting for American Association for Cancer Research, April 6-10, 2013. Washington DC, USA.
14. Kuo YZ, Huang YC, Chen YL, Lo HI, Tsai ST, and Wu LW*. Identification of deregulated miRs and its target genes in head and neck cancer. The 104th Annual Meeting for American Association for Cancer Research, April 6-10, 2013. Washington DC, USA.
15. Wu LW*. Diagnostic and Therapeutic Potential of Using microRNA for Oral Cancer Treatment: Insight from miR-99a. Frontiers in Translational Medicine 2013, Kaohsiung, Taiwan (Keynote speaker).
16. Kuo YZ, Huang YC, Tsai ST and Wu LW*. MiR-22 down-regulation via epigenetic control in oral cancer cells. Noncoding RNAs and Cancer, Miami, USA, Jan 8-11, 2012.
17. Chen MH, Tsai ST, and Wu LW*. Functional implication of deregulated PTPRR expression in oral cancer. The Society of Chinese Bioscientists (SCBA) in American 12th International Symposium, Guangzhou, China, July 25-29, 2011.
18. Tsai ST, Tsai WC, and Wu LW*. Coding nucleotide polymorphism 185G>A in the S100A2 gene has no effect on S100A2-mediated anti-tumorfunction in oral cancer. 4th World Congress of International Federation of Head and Neck Oncologic Societies. Seoul, Korea, June 15-19, 2010.
19. Lin YY, Peng CY, Hsu YY, and Wu LW*. Evidence and actions for nuclear localization of vascular endothelial growth factor receptor 1 (VEGFR1) in endothelial and cancer cells The 101th Annual Meeting for American Association for Cancer Research, Washington DC, USA, April 17-21, 2010.
20. He MF, Huang YH, Ge W, Shaw PC, But PPH*, and Wu LW*. Triptolide functions as a potent angiogenesis inhibitor. Asia-Pacific Conference of Tumor Biology and Medicine, Xi-An, China, Oct 24-27, 2009.
21. Chao TL, Kuo YZ, Tsai ST, and Wu LW*. CpG island methylation is not the sole mechanism responsible for S100A2 mRNA down-regulation in oral cancer cells. The Society of Chinese Bioscientists in American 12th International Symposium, Taipei, Taiwan, June 14-18, 2009.
22. He MF, Huang YH, But PPH*, and Wu LW*. Triptolide inhibits tumor angiogenesis via blocking endothelial receptor-mediated signaling pathways. The Society of Chinese Bioscientists in American 12th International Symposium, Taipei, Taiwan, June 14-18, 2009.
23. Pan SC, Wu LW*, Chen CL, Shieh SJ, and Chiu HY*. The role of burn blister fluid in the recruitment and differentiation of circulating angiogenic cells during burn would healing: a comparison of superficial and deep partial thickness burn wounds. Jointed “Annual Meeting of Taiwan Society for Stem Cell Research” and “The International Symposium of Stem Cells and Bioengineering”, Tainan, Taiwan, May 16- 17, 2009.
24. Wu LW*, Chen IH and Tsai ST. Glycolytic ENO1 is a prognostic marker for oral squamous cell carcinoma. The 100th Annual Meeting for American Association for Cancer Research, Denver, CO, USA, April 18-22, 2009.
25. Wu LW (invited speaker). Overexpression of ENO1, a novel prognostic marker for oral carcinogenesis, enhances tumorigenesis via altering gene expression.  The 12th Annual Asia-Pacific Congress on Oral Cavity, Taipei, Taiwan, Dec 6-7, 2008.
26. Wu LW (corresponder), Chen YH and Huang YH. Angiostatin K1-3 induces E-selectin via AP1 and Ets1: a mediator for anti-angiogenic action of K1-3. The 99th Annual Meeting for American Association for Cancer Research, San Diego, CA, USA, April 12-16, 2008.
27. Wu MP, Young MJ, Wu LW*, Chou CY*.  A novel role of thrombospondin-1 in cervical carcinogenesis:Inhibit stroma reaction by inhibiting myofibroblast from invading cancer.  International Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan, Nov 18-19, 2007, Tainan, Taiwan.
28. Wu LW (Invited Speaker). E-selectin as a novel target for the anti-angiogenic action of angiostatin K1-3. The first International Symposium. Nov 16-17, 2007. Taichung, Taiwan.
29. Wu LW*, Hu HT, Huang YH, Lee CK and Su WC. Tie2-R849W mutant chronically induces constitutive activation of STAT-1 via a distinct signaling pathway. The 98th Annual Meeting for American Association for Cancer Research, Los Angeles, CA, USA, April 14-18, 2007.
30. Wu LW*, Huang YH, Shen WH and Chu JM. Role of Egr-1 in regulation of caveolin-1 gene expression in endothelial cells. The 97th Annual Meeting for American Association for Cancer Research, Washington DC, USA, April 1-5, 2006.
31. Wu LW*, Chiang YM, Chuang HC, Lo CP, Yang KY, Wang SY, and Shyur LF. A novel polyacetylene inhibits angiogenesis and induces apoptosis in human endothelial cells. The 53rd Annual Congress for Society for Medicinal Plant Research, Florence, Italy, Aug 21-25, 2005.
32. Wu LW, Yang KY, Tsai ST*. Cyclooxygenase 2-dependent autocrine action of amphiregulin in oral cancer cells. The 96th Annual Meeting for American Association for Cancer Research, Orange County, CA, USA, April 16-20, 2005.
33. Tsai WC, Tsai ST*, and Wu LW*. The tumor suppression role of S100A2 in human carcinoma cells. The 96th Annual Meeting for American Association for Cancer Research, Orange County, CA, USA, April 16-20, 2005.
34. Chen YH, and Wu LW*. Investigation of angiostatin-induced signal transduction pathway in human endothelial cells. The 4th Asian-Pacific Organization for Cell Biology. Taipei, Taiwan, Nov 3-6, 2002.  
35. Tsai WC, Tsai ST*, Wu LW*. Profiling expression of genes in betel-quid chewing related oral cancers. The 4th Asian-Pacific Organization for Cell Biology. Nov 3-6, 2002.
36. Wu LW*, Lien WH, Tsai WC, Yang GW, and Li C. Distinct regulation of genes by bFGF or VEGF-A in human endothelial cells. Abs# 226, Keystone Symposium on Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy, Banff, Alberta, Canada, Feb 8-12, 2002.
37. Lau KHW, Suhr SM, Wu LW, and Baylink DJ*. The Protein-Tyrosine Phosphatase (PTP) Activity of PTP-oc Is Required for the Dephosphorylation of PY527 and Activation of c-Src in Osteoclasts. American Society of Bone and Mineral Research, U.S.A., Sept, 2001".
38. Wu LW*, Jih YJ, Lien WH, and Chen YJ. Profiling expression of genes regulated by an angiogenic inducer, bFGF, in human endothelial cells. Keystone symposium on Angiogenesis and chronic diseases, Keystone, USA, April 24-29,2001

b. 國內會議

1. Huang LC and Wu LW*. DCBLD1 deregulation and its action mechanism in esophageal cancer. The Thirty-sixth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 26-27, 2022.
2. Tsai CJ and Wu LW.The deregulation of PIK3C2B, a class II PI3K family member, uncoupled cell migration from invasion in oral cancer. The Thirty-sixth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 26-27, 2022.
3. Chang CH, Hsieh TC, Tsai ST, and Wu LW. The intracellular and extracellular role(s) of YES-associated protein in oral carcinogenesis. The Thirty-third Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 24-25, 2018.
4. Chang CY, Huang YH, Tsai ST and Wu LW. CCL22/CCR4 signaling axis participates in the crosstalk between oral cancer cells and microenvironment. The Thirty-third Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 24-25, 2018.
5. Kuo YZ, Fang WY, Huang CC, Tsai ST, Wang YC, Yang CL, and Wu LW. Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer. The Taiwan Society for Biochemistry and Molecular Biology Autumn Camp, Kaohsiung, Taiwan, Nov 17-19, 2017.
6. Li CY, Pan SC, Kuo YZ, Fang WY and Wu LW*. Calcium-binding S100A2 impaired cutaneous qound healing by modulating P53 activity. The Thirty-twelfth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 25-26, 2017.
7. Kang YR, Hsieh TC, Chang WL, Wang YC and Wu LW*. Contrasting Roles of Hippo Pathway Deregulation in Esophageal Cancer. The Thirty-twelfth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 25-26, 2017.
8. Huang YH, Kuo YZ, Fang WY and Wu LW*. The impact of epithelial S100A2 expression on upper aerodigestive track carcinogenesis. The Thirty-First Joint Annual Conference of Biomedical Sciences, March 26-27, 2016. Taipei, Taiwan.
9. Hsieh TC, Tsai ST, Wu LW*. Studying the Role of YES-associated protein in oral cancer. The Thirty-First Joint Annual Conference of Biomedical Sciences, March 26-27, 2016. Taipei, Taiwan.
10. Kuo CY, Pan SC, Kuo YZ, Fang WY, Tsai ST, and Wu LW*. A requirement of calcium-binding protein S100A2 for P53-mediated cutaneous wound healing. The Thirtieth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 21-22, 2015.
11. Yang CL, Fang WY, Kuo YZ, Wu LW*. Studying the molecular mechanism responsible for the down-regulation of TGFBR3 in oral cancer. The Twenty-Eighth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 23-24, 2013.
12. Chen YW, Lin SH, Fang WY, Tsai ST, Wu LW*.  Studying the Role of Calprotectin in Oral Cancer and Stromal Cells. The Twenty-Eighth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 23-24, 2013.
13. Huang YC, Kuo YZ, Tsai, ST and Wu LW. Epigenetic control involved in the down-regulation of miR-22 in oral cancer cells. The Twenty-Seventh Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18, 2012.
14. Chen MH, Su WP, and Wu LW*. Functional implication of protein tyrosine phosphastase receptor-type R (PTPRR) in oral cancer. The Twenty-Sixth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 10-20, 2011.
15. Wu HL, Chu JM, Chang MZ and Wu LW*. Characterization and functional implication of nuclear thrombomodulin. The Twenty-Fifth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 27-28,2010.
16. Hsu YY, Hung CC, Shen WH, Tsai ST, Chen YL, and Wu LW*. Tumor suppressor S100A2 suppresses the glycolytic activity of enolase 1 via direct interaction. The Twenty-Fifth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 27-28, 2010.
17. Tsai WC, Shen WH, Tsai ST, and Wu LW*.  G182A polymorphism in S100A2 coding sequence: lack of association with the anti-tumor effect by S100A2 in oral cancer cells.  The Twenty-Fourth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 21-22, 2009.
18. Wu LW (invited speaker). Overexpression of ENO1, a novel prognostic marker for oral carcinogenesis, enhance tumorigenesis vial gene expression.  The 12th Annual Asia-Pacific Congress on Oral Cavity, Taipei, Taiwan, Dec 6-7, 2008.
19. Chien IH, Tsai ST and Wu LW*. ENO1 is an oncogene in human oral squamous cell carcinoma. The Twenty-Third Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 29-30. 2008.
20. Peng CY and Wu LW*. Identification of a Functional Nuclear Localization Sequence (NLS) in Vascular Endothelial Growth Factor Receptor 1 (VEGFR1). The Twenty-Third Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 29-30. 2008.
21. Wang HP, Shen WH and Wu LW*.  Egr-1-mediated vascular permeability via Cav-1 repression. The Twenty-Third Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 29-30. 2008.
22. Lin YY and Wu LW*.  The underlying mechanism for discrete sublocalization of VEGF-A receptors in cancer cells. The Twenty-Second Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18. 2007.
23. Shen WH, Tsai ST, and Wu LW*. Molecular and functional studies of S100A2-interacting proteins involved in the anti-tumor effect of S100A2. The Twenty-Second Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 17-18. 2007.
24. Chen YT, Wu HL, Li C, Huang YH, Wu MP, and Wu LW*. Delineation of the molecular mechanism of angiogenesis mediated by multiple forms of angiostatin (oral presentation).  The Twenty-first Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 18-19. 2006.
25. Tsai WC, Tsai ST, Jin YT, and Wu LW*.  The tumor suppression role of S100A2 in human sqaumous cell carcinoma cells (oral presentation). The Twenty-first Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 18-19. 2006.
26. Hu HT, and Wu LW*. Molecular characterization of Tie2(R849W)-mediated signaling pathways in endothelial cells.  The Twenty-first Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 18-19. 2006.
27. Jian YZ, Tsai ST, and Wu LW*.  The underlying mechanism of amphiregulin-induced COX-2 in oral cancer cells. The Twenty-first Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 18-19. 2006.
28. Lin YC, Tsai ST, Jin YT, Tsai WC, Wang ST, Chang MT, and Wu LW*. Early detection of recurrence with S100A2 protein expression in early stage oral cancer patients. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan. Jan 26-28, 2005.
29. Yang KY, Tsai ST and Wu LW*. Functional analysis of amphiregulin in oral cancer cells. The Nineteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, April 19-11, 2004.
30. Wu LW. Common and distinct mechanism triggered by two angiogenic inhibitors, angiostatin and TNP-470. The eighteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 22-23, 2003.
31. Huang YH, Chen YH, and Wu LW*.  Implication of tyrosine phosphorylation and dephosphorylation in the regulation of angiogenesis. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan. Jan 20-22, 2003.
32. Chen CK, Lien WH, Lai LY, and Wu LW*. Molecular Mechanism of TNP-470 induced cell cycle arrest in G1. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan. Jan 20-22, 2003.
33. Chen YH and Wu LW. Delineation of signal transduction pathway mediated by angiostatin in human endothelial cells. The seventeenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 23-23, 2002.
34. Lien WH, and Wu LW*. Identification of genes modulated by an angiogenic inhibitor, TNP-470, in endothelial cells. The seventeenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 23-23, 2002.
35. Chen YJ, Jin YT, Shieh DB, and Wu LW*. The role of angiogenesis in oral cancer cells. Ninth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, Feb 2-5, 2001.
36. Wu LW, Mayo LD, Dunbar JD, and Donner DB*. Utilization of distinct signaling pathways by receptors for VEGF and other mitogens in the induction of endothelial cell proliferation. Eighth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, Jan 29-31, 2000.