陳粲然Publication

 

陳粲然大頭貼

研究成果 (Publications)

A. 期刊論文 (Peer-reviewed papers)

  1. Chen TJ, Lo CJ, Wu MJ, Sit WY, Hsu HY, Huang YC, Lu CH, Chen YL, Fang WK, Yang SM, Chen PL, Haraguchi T, Hiraoka Y, Lin CY, Cheng ML, Yang MH, Kung HJ, Wang WC* (2025) GSH as an A-A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility. Adv Sci (Weinh): e19368
  2. Chen TJ†, Wu CH†, Hung MC, Wang WC*, Kung HJ* (2025) Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator. J Biomed Sci 32: 75
  3. Wu MJ, Yang SM, Fang WK, Chen TJ, Wu CY, Hsu YJ, Shen CE, Cheng YC, Hsieh WC, Yuh CH, Yang MH, Kung HJ, Wang WC* (2025) KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma. Cell Mol Life Sci 82: 170
  4. Sit WY, Cheng ML, Chen TJ, Chen CJ, Chen BN, Huang DJ, Chen PL, Chen YC, Lo CJ, Wu DC, Hsieh WC, Chang CT, Chen RH, Wang WC* (2024) Helicobacter pylori PldA modulates TNFR1-mediated p38 signaling pathways to regulate macrophage responses for its survival. Gut Microbes 16: 2409924
  5. Liu JS, Fang WK, Yang SM, Wu MC, Chen TJ, Chen CM, Lin TY, Liu KL, Wu CM, Chen YC, Chuu CP, Wang LY, Hsieh HP, Kung HJ, Wang WC* (2022) Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. J Biomed Sci 29: 29
  6. Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ*, Chien S, Wang WC* (2019) KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis. Cell Death Dis 10: 68
  7. Chen TJ†, Wang HJ†, Liu JS, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ*, Wang WC* (2019) Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun Biol 2: 105
  8. Lai CH*, Huang JC, Cheng HH, Wu MC, Huang MZ, Hsu HY, Chen YA, Hsu CY, Pan YJ, Chu YT, Chen TJ, Wu YF, Sit WY, Liu JS, Chiu YF, Wang HJ, Wang WC* (2018) Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages. Cell Microbiol 20: e12947
  9. Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM*, Kung HJ*, Wang WC* (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem 57: 5975-85

B. 研討會論文 (Conference papers)

  1. Chen TJ, Lo CJ, Cheng ML, Lin CY, Yang MH, Kung HJ, Wang WC*, PKM2 regulates redox homeostasis and ferroptosis susceptibility by acting as a GSH binding protein, The 19th Conference of Asian Crystallographic Association (AsCA 2025), Dec. 01-06, 2025, Taipei, Taiwan.
  2. Chen TJ, Wang WC, Structural investigation of druggable targets in the metabolic pathway of Pathogens and cancer, The 3rd User Training Workshop for NSTCCore Computing Service, Oct. 15, 2025, NTHU, Hsinchu, Taiwan.
  3. Chen TJ, Lo CJ, Cheng ML, Lin CY, Yang MH, Kung HJ, Wang WC*, PKM2 is allosterically regulated by GSH to confer ferroptosis susceptibility, NSRRC 31st Users' Meeting & Workshops, Sept. 02-04, 2025, Hsinchu, Taiwan.
  4. Chen TJ, Wu MJ, Fang WK, Wang WC*, Targeting KDM4B-mediated epigenetic reprogramming for therapeutic intervention in castration-resistant prostate cancer, 2024 International Conference on Advanced Biomedical Sciences (ICABS), Oct. 25-26, 2024, Taichung, Taiwan.
  5. Chen TJ, Wu MJ, Fang WK, Wang WC*, KDM4 family proteins are metabolic regulators and potential anti-cancer targets in prostate and oral cancers, Cold Spring Harbor Laboratory Meeting, Biology of Cancer: Microenvironment & Metastasis, Sept. 19-23, 2023, New York, US.
  6. Chen TJ, Wang HJ, Liu JS, Wang WC*, PKM2 exon-10 mutations drive reduced allostery and increased oncogenicity, NSRRC 25th Users’ Meeting & Workshops, Sept. 17-20, 2019, Hsinchu, Taiwan.