Educations / Professional Experience

Educations

1993-1998

Ph.D. Graduate student Department of Biology and Division of Geographic Medicine University of Alabama at Birmingham,Birmingham, Alabama, U.S.A.

1988-1990

M.S., Graduate Institute of Microbiology and Immunology National Yang-Ming University, Taipei,Taiwan, R.O.C.

1984-1988

B.S., Biology, National Cheng-Kung University, Tainan, Taiwan, R.O.C.

Current Position

2010-present

Associate Professor, Institute of Molecular Medicine, National Cheng Kung University Medica College

Professional

  Experience

2003-2010

Assistant Professor, Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan

1998-2003

Postdoctoral Research Fellow, Department of Pediatrics and Vanderbilt-Ingram Cancer center, Vanderbilt University, Nashville, TN, U.S.A

1993-1998

Graduate assistant, Department of Biology and Division of Geographic Medicine University of Alabama at Birmingham Birmingham, Alabama, U.S.A.

1992-1993

Research assistant, Dr. Chen-Kung Chou’s lab Endocrinology Laboratory, Taipei Vetera General Hospital, Taiwan. Studies on the regulation of Hepatitis B Virus gene expression by retinoids

Expertise /Research Interests

Protein phosphatase, signal transduction, tumor biology

Research Interests

My research has been focusing on studying protein phosphatase 2A (PP2A), which consists of three subunits, including a structural subunit A, a catalytic subunit C, and a highly variable B regulatory subunit. There are four subfamilies of B regulatory subunits and these diverse B subunits confer a complexity to PP2A. We have studied the molecular mechanisms of the tumor suppression activity of PP2A and also investigated the cellular functions of the B regulatory subunits, especially the B56γ3 subunit. We recently found a potential oncogenic role of the B56γ3 subunit-containing PP2A in colorectal cancer cells and are investigating the molecular mechanism underlying this novel oncogenic role of PP2A and validating this property in mouse tumor model. Moreover, we are also interested in investigating the liquid-liquid phase separation (LLPS) of proteins and in delineating the role of LLPS in regulating the signaling complex consisting of PP2A and its interacting partners in cellular functions and cancer development.

Research

Directions

1. To investigate the oncogenic role of the B56γ3 subunit-containing PP2A 

2. To investigate the interaction between PP2A and the PI3K/AKT/mTOR/p70S6K signaling pathway.

3. To investigate the role of LLPS in regulating PP2A and its interacting partners in cellular functions and cancer development