Publications

1. Wu PM, Cho HY, Chiang CW, Chuang TH; Wu SN, Tu YF. (2022 July) Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na+ and Erg-Mediated K+ Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line. Int. J. Mol. Sci. 23, 7892.

2. Wu PM, Yu WH, Chiang CW, Wu CY, Chen JS, Tu YF. (2022 Feb) Novel Variations in the KDM5C Gene Causing X-Linked Intellectual Disability. Neurology. Genetics. 8(1):e646.

3. Tu YF, Jiang ST, Chiang CW, Chen LC, Huang CC. (2021 Jun) Endothelial-specific insulin receptor substrate-1 overexpression worsens neonatal hypoxic-ischemic brain injury via mTOR-mediated tight junction disassembly. Cell Death Discov. 7(1):150.

4. Wang M, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Ferreira RB, Chiang CW, Guryanova OA, Kopinke D, Heldermon CD, Castellano RK, Law BK. (2019 Dec) Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Cell Death Discov. 10;5:153.

5. Wang CH, Hung PW, Chiang CW, Lombès M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. (2019 Aug) Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Biochim Biophys Acta Mol Cell Res.;1866(8):1282-1297.

6. Wang M, Ferreira RB, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Sharma A, Avery BA, Rodriguez E, Chiang CW, Narayan S, Heldermon CD, Castellano RK, Law BK. (2019 May) A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers.Oncogene.;38(22):4264-4282. doi: 10.1038

7. Lin CH, Shen YR, Wang HY, Chiang CW, Wang CY, Kuo PL. (2019 Jan) Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly.Cytoskeleton (Hoboken). 76(1):137-142

8. Tzeng HT, Li TH, Tang YA, Tsai CH, Lu FPJ, Lai WW, Chiang CW and Wang YC. (corresponding) (2017 Sep) Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget. 8(65):108556-108570.

9. Liao SY, Chiang CW , Hsu C H, Chen Y T, Jen J, Juan HF, Lai WW, and Wang YC.(2017 Jun) CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression. Oncogene, 12;36(41):5722-5733

10. Lai TY, Yen CJ, Tsai HW, Yang YS, Hong WF, Chiang CW (2016 Jan) The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1 Oncotarget.7(4):4542-58,

11. Yang CP, Kuo YL, Lee YC, Lee KH, Chiang C W, Wang J M, Hsu C C, Chang WC, Lin DY. (2016 Sept) RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. Biochem Biophys Res Commun. 16;478(2):873-80.

12. Yang CP, Chiang CW, Chen CH, Lee YC, Wu MH, Tsou YH, Yang YS, Chang WC, Lin DY. (2015 May). Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). J Biomed Sci.2233-47

13. Mo ST, Chiang S J, Lai T Y, Cheng Y L, Chung C E, Kuo S C H, Reece K M, Chen Y C, Chang N S, Wadzinski B E, and Chiang CW. (2014 Dec) Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells.  PLoS One 9(12):e116074

14. Tseng YT, Wang S W, Kim KS, Wang YH, Yao Y, Chen C.C, Chiang CW, Hsieh PC, and Teng CH. (2012 Oct) NlpI Facilitates deposition of C4bp on Escherichia coli by blocking classical complement-mediated killing, which results in high-level bacteremia. Infection and immunity. 80:3669-78.

15. Yen CJ, Lin YJ, Yen CS, Tsai HW, Tsai TF, Chang KY, Huang WC, Lin PW, Chiang CW, Chang T T. (corresponding). (2012 Jul) Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma. PLoS One. 7(7):e41931.

16. Chiang CW, Liu W. K., Chiang CW, Chou CK. (corresponding). (2011 Jan) Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5. Biochem J. 433(1):187-96.

17. Hsu CC, Chiang CW, Cheng H C, Chang WT, Chou CY, Tsai HW, Lee CT, Wu ZH, Lee T Y, Chao A, Chow NH, Ho CL. (2011 Feb) Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach. Oncogene. 30 (6):654-667

18. Lee T Y, Lai T Y, Lin SC, Wu CW, Ni IF, Yang Y S, Hung LY, Law B K, and Chiang CW. (2010 Jul) The B56γ3 Regulatory Subunit of Protein Phosphatase 2A(PP2A) Regulates S Phase-specific Nuclear Accumulation of PP2A and the G1 to S Transition. J. Biol. Chem. 285 (28): 21567-21580

19. Chen SH, Wang YW, Hsu JL, Chang H Y, Wang CY, Shen P T, Chiang CW, Chuang J J, Tsai H W, Gu PW, Chang FC, Liu HS, Chow N H. (2010 Jan) Nucleophosmin in the pathogenesis of arsenic-related bladder carcinogenesis revealed by quantitative proteomics. Toxicol. Appl. Pharmacol. 242:126-135

20. Chiang CW, Yan L, Yang E. (2008) Phosphatases and regulation of cell death. Methods in Enzymology. 446:237-257

21. Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY and Chiang CW. (2008 Jan) Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt, J Biol. Chem. 283(4):1882-1892.

22. Wang Q F, Chiang CW, Wu CC, Cheng C C, Hsieh SJ, Chen JC, Hsieh Y C, Hsu S L. (2007 Jun) Gypenosides induce apoptosis in human hepatoma Huh-7 cells through a calcium/reactive oxygen species-dependent mitochondrial pathway. Planta Med. 73(6):535-44.

23. Lin CF, Chen CL, Chiang CW, Jan M S, Huang W C and Lin YS. (2007 Aug) GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.J Cell Sci. 15;120(Pt 16):2935-43.

24. Chen CL, Lin C F, Chiang C W, Jan M S and Lin Y S. (2006 Aug) Lithium Inhibits Ceramide- and Etoposide-induced PP2A Methylation, Bcl-2 Dephosphorylation, Caspase-2 Activation and Apoptosis. Molecular Pharmacology. 70(2):510-517.

25. Chen YH, Wu HL, Li C, Huang Y H, Chiang CW, Wu MP, Wu LW. (2006 Apr) Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation. Thromb Haemost. 95:668-677

26. Chiang CW, Kanies C, Kim K W, Fang W B, Parkhusrt C, Xie M, Henry T, and Yang E. (2003 Sep) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell Biol. 23:6350-6362

27. Chiang CW, Harris G, Ellig C, Masters S C, Subramanian R, Shenolikar S, Wadzinski B, and Yang E. (2001 Mar) Protein phosphatase 2A activates the pro-apoptotic function of BAD in Interleukin-3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood. 97:1289-1297

28. Chattopadhyay A, Chiang C W, and Yang E. (2001 Jul) BAD/BCL-xL heterodimerization leads to bypass of G0/G1 arrest. Oncogene.20:4507-4518

29. Hsu SL, Cheng C C, Shi YR, and Chiang C W. (2001 Jun) Proteolysis of integrin a5 and b1 subunits involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Cancer Letters. 167:193-204

30. Chiang CW, Carter N, Sullivan W J. Jr, Donald R G K, Roos DS, Fardos N M Naguib, Mahmoud el Kouni, Ullman B, and Wilson C M. (1999 Dec) The adenosine transporter of Toxoplasma gondii :Identification by insertional mutagenesis, cloning, and recombinant expression. J. Biol. Chem. 274:35255-35261

31. Sullivan WJ, Chiang C W, Wilson CM, Fardos NM Naguib, Mahmoud el Kouni, Donald R G K, and Roos DS. (1999 Sep) Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus. Mole. Biochem. Parasitol. 103(1): 1-14