Educations / Professional Experience

Educations

1997-2001

B.S.,Department of Life Science at Fu Jen Catholic University, Taiwan, R.O.C)

2001-2002

M.S., Institute of Molecular Medicine, National Cheng-Kung University, Taiwan, R.O.C.

2002-2007

Ph.D. Institute of Basic Medical Science, National Cheng-Kung University, Taiwan, R.O.C.

Current Position

2019/2-

Postdoctoral fellow, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan, Taiwan, ROC

Professional Experience

2023/08-

Postdoctoral fellow, An-Nan Hospital, China Medical University, Tainan, Taiwan

2019/02-

Adjunct assistant professor, Institute of Molecular Medicine, National Cheng-Kung University, Taiwan, R.O.C.

2011/08-

Postdoctoral fellow, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan, Taiwan, ROC

2008/08-2011/07

Assistant professor, Department of Biotechnology, MingDao University, Taiwan, ROC

2007/10-2008/07

Postdoctoral fellow, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan, Taiwan, ROC

Expertise /Research Interests

Research Interests

1. Chronic Liver Diseases and Liver Cancer Research

1.1 This study investigates the role of microbiota in liver tissue, feces, and oral cavity and its related factors in hepatocellular carcinoma and cholangiocarcinoma, seeking biomarkers for postoperative recurrence. The gut microbiome has recently been considered a major environmental factor affecting the pathogenesis of various human diseases. Previous studies have discussed the impact of the "gut microbiome" on liver diseases rather than the "liver microbiome." This research will use next-generation sequencing analysis to study the microbiota in liver tissues, feces, and the oral cavity of patients with different types of liver cancer (hepatocellular carcinoma, cholangiocarcinoma, hepatic hemangioma), analyzing their metabolomic profiles, immunomic profiles, and the mechanisms of interaction with viruses over a long-term follow-up. Preliminary results indicate that specific microbiota are associated with liver cancer recurrence and related clinical manifestations.

1.2 The study explores the dynamics between serum hepatitis B surface antigen, pre-genomic RNA (pgRNA), hepatitis B virus DNA, and cell-free DNA in the blood, to serve as indicators for drug treatment efficacy, patient recovery, and relapse.

2. Neuroscience Research

2.1 The impact of COVID-19 infection on the disease course and medication improvement in patients with schizophrenia: This study examines how COVID-19 infection changes the severity of the disease course and related immune changes in patients with schizophrenia, particularly regarding new psychiatric symptoms induced by COVID-19.

2.2 The interaction between microbiota and neuroimmunity in neurodegenerative diseases: This research explores the interaction between the gut microbiota and the brain's immune system, especially regarding the neuroinflammatory mechanisms related to Parkinson's Disease (PD).

2.3 The effect of Omega-3 polyunsaturated fatty acid (PUFA) intake on vasomotor symptoms, sleep quality, and depression in postmenopausal women: This study investigates how fish oil supplementation can serve as a potential adjunctive treatment for mental health conditions, including depression.

2.4 Brain stimulation and imaging techniques in psychiatric diseases: Research in the treatment and diagnosis of psychiatric diseases has shown significant benefits from brain stimulation and imaging technologies. Advanced techniques such as near-infrared spectroscopy (NIRS) and repetitive Transcranial Magnetic Stimulation (rTMS) offer new insights into the treatment of major depressive disorder (MDD). This study uses NIRS for the differential diagnosis of complex psychiatric diseases such as major depression, bipolar disorder, and schizophrenia, also showing progress in identifying biomarkers and developing objective diagnostic tools.