國立成功大學分子醫學研究所碩士班課程介紹

（★英語授課 English Course）

高等分子生物學（Advanced Molecular Biology）-104學年新生適用

任課老師：張南山、蔣輯武、吳梨華、孫孝芳、鄧景浩、賴明德等(必修，3學分、開授學期：碩一上)

將生物現象的種種機能循分子層次進行研究之分子生物學是生物學結合物理學、化學而發展出的新科學領域，隨著分子生物學之進展所開發出之基因工程技術，是探討生命科學奧妙，造褔人類重要之科學技術之一。本課程以真核細胞分子生物為主，並補充介紹目前基因工程所採用之重要技術的理論、方法實驗與實例等。

(1) To assist the graduate students in understanding the history and Future challenges of molecular biology from discovery of DNA to genome sciences, and (2) To provide the students insights of modern molecular biology tools and computational approaches for experimental design and problem shooting.

高等細胞生物學 (Advanced Cell Biology) -104學年新生適用

任課老師：吳梨華、蔣輯武、王憲威、鄧景浩等(必修，3學分、開授學期：碩一上) 　

本課程屬於中階的細胞生物學，選課學生最好要修過生化或生命科學等相關科目。課程內容著重於在分子層次探討動物細胞和致病菌之結構、功能和信號傳遞，及細胞增生、分化與死亡的機轉，並介紹傳統與新穎的細胞生物技術。最後，以免疫細胞、神經細胞、寄主與致病菌交互作用與癌症的形成為主題，探討這些細胞如何因結構或功能失調而導致人類疾病。

Familiarize students with the fundamentals of cell biology and with the application of this knowledge in addressing both basic and clinical research questions. By the end of the course, students would know the basics of fundamental cell biology and how to apply what they learn in addressing cell biology-related questions arising in the research field of their interest, including cancer biology, immunology, neurobiology, microbial pathology, and developmental biology.

專題討論一、二、★三、★四 (Seminar I, II, III, IV)

任課老師：張南山、孫孝芳、吳梨華、蔣輯武、王憲威、鄧景浩、等全體老師(必修，各1學分、開授學期：碩一上、下、二上、下)

本課程之目的為培養學生閱讀論文，並提高學生發表論文之技巧，本課程規定每位研究生每學期至少需報告一篇其感興趣之科學文獻，或畢業論文有關之研究成果。

Enrolled students are required to orally present a paper published within the last 12 months. The selected paper should not be directly related to the research field of the presenter, in order to broaden his/her knowledge.

生物資訊（Bioinformatics）

任課老師：孫孝芳等(選修，3學分、開授學期：碩一、碩二上)

藉由個案分析、範例練習中學習網路資源的運用。

The principal learning objective is for the students to recall familiarity with basic building blocks of bioinformatics through case report and example exercise, to enable them to subsequently tell a more detailed knowledge of those particular aspects of bioinformatics in basic scientific research that interest them by using online bioinformatics resources. 

★研究導論 (Introduction to Research)

任課老師：蔣輯武等(選修，2學分、開授學期：碩一、碩二上)

介紹和探討研究倫理，實驗紀錄法，實驗的安全，科學的讀、說、寫，研究的方法與運用，以及台灣生科企業的發展，以助新進碩博班學生從事生醫方面的研究。

This course introduces graduate students to scientific integrity and research ethics, biosafety, time management, hypothesis testing, scientific reading and communication, abstract/poster/proposal writing, and an overview of various biomedical methodologies and technologies. Students will also be exposed to current biotechnology and pharmaceutical developments or job opportunities in Taiwan and Asia.

癌症分子病理學 (The Molecular pathology of Cancer)

任課老師：何中良、周楠華等(選修，2學分、開授學期：碩一、碩二下)

惡性腫瘤連續佔台灣地區主要死亡原因之首，部份癌症更有年輕化的趨勢。而且國內癌症病患的平均存活率相較於美國則仍明顯偏低，顯示國人在癌症研究的努力上仍有很大的改善空間。本課程是以分子生物學的角度，去了解人類癌症的發生機轉, 以及國人重要癌症的各自特殊之致癌路徑。每個主題都邀請鑽研此一癌症的老師授課。在人類基因計劃公佈解讀出的基因序列資料之後,為人類疾病(尤其是癌症)找到真正的基因基礎，是未來醫學的主流之一。選修學生可以更深入了解現今腫瘤醫學的進步。也可在此一基礎上, 思考如何在後基因體時代,找尋創新的癌症診斷,及更有效治療之方式。

The course is designed to teach students to understand the mechanisms and the specific pathway of human cancer. The goal of this course is to provide the students an in-depth understanding of the development in tumor medicine and thinking how to find a novel diagnosis and more effective treatments in cancer.

癌症醫學 (Cancer Medicine)

任課老師: 張南山、蘇五洲等 (選修，2 學分, 開授學期: 碩一、二下)

惡性腫瘤連續佔台灣地區主要死亡原因之首, 而且部份癌症更有年輕化的趨勢, 提醒我們對癌症的了解,預防及治療, 仍然有許多有待突破的瓶頸。目前知道, 70%的癌症來自飲食與生活的失調。因此針對高危險群病患推廣預防癌症的措施, 以及推動癌症早期篩檢, 早期治療等都是根本解決的最重要方向。 因此, 本課程是介

紹現今治療癌症主要的基本原理, 應用飲食控制來預防癌症發生的理論, 或是各種早期診斷癌症研究等近況。 每個主題都邀請鑽研此一題目的老師授課。 選修學生可以更深入了解現今腫瘤醫學的進步。 也可在此一基礎上,找尋在後基因體時代可能的敏感早期癌症篩檢, 或是早期治療之方式。

Malignant neoplasm is the leading cause of death in Taiwan in recent 30 years and some of them have shown a trend toward younger age at diagnosis. Currently, 70% of human cancers can be attributed to environmental factors and life style. This course is designed to introduce basics of contemporary cancer therapy and provide more understandings of cancer prevention and tumor diagnosis. Experts of the relevant field will be invited for each subject. By the end of this course, students could have a better concept of advances in cancer medicine. The knowledge is of great help in the post-genomics era in search for early screening and effective treatment for human cancer.

血管新生學 (Angiogenesis)

任課老師：吳梨華等(選修，2學分、開授學期：碩一、碩二下)(104.12.31修正)

探討血管新生的分子機制及其在動物胚胎發育，傷口的癒合，女性生殖週期以及腫瘤生成蔓延所扮演的角色，之後小組書報討論最新血管新生作用機轉，同時藉由醫師現身說法分享應用血管新生療法治療疾病的經驗。

An overview on the factors and cell types involved in new blood vessel formation and the relation of their deregulation with the development of human diseases. In addition to journal paper discussion on the latest reports on angiogenesis, three physicians will also share their bedside experience of treating vascular disease with angiogenic therapies.

細胞程序性死亡的分子機轉 (The molecular mechanisms of the programmed cell death)

任課老師：蔣輯武、張南山等(選修，2學分、開授學期：碩一、碩二上) -111學年新生適用

本學門旨在傳授有關細胞程序性死亡的分子機轉，特別是在細胞凋亡的方面。此課程的內容包含細胞程序性死亡及細胞凋亡的基本概念以及調控這些細胞死亡的分子機轉。指引學生對細胞程序性死亡能有更深入的瞭解，並探討在細胞程序性死亡研究領域的最新發現。

This course covers the topics of molecular mechanisms that regulate the programmed cell death (PCD), especially on apoptosis. Topics include an overview of PCD; introduction to apoptosis; molecular mechanisms regulating  apoptosis and other non-apoptotic PCD such as necroptosis, pyroptosis and ferroptosis. The primary goal of this course is to let students gain mechanistic insights regarding apoptosis and non-apoptotic PCD and learn recent findings in the PCD field.

老化研究特論 (Special Topics on Aging Research)

任課老師 : 蔣輯武、陳昌熙等(選修，2學分、開授學期：碩二下) -103學年新生適用

在世界已開發國家中，因經濟高度發展及醫藥發達，社會高齡化趨勢與日俱增。因此，老人醫學是現在世界各國重視與加強發展的學門。重要的是，研究老化與老化相關的生命科學領域也正崛起。這門課程的目標，是期望將老化研究領域中的重要文獻背景做回顧，並探討最近的突破與發現。並希望藉由介紹老化研究領域的研究模式，讓學生能從單一細胞老化、到生物體的衰老的已知機制與模式能有廣泛的認知。        

This course is designed to cover the topics on aging and aging-related research disciplines, such as regulation of cellular senescence, model systems for aging research, aging genetics, signal transduction in aging process, anti-aging research, mitochondrial biology, DNA repair and chromosome stability in aging, and cancer in aging. After completing this course, students can gain novel concepts of aging and a broad view of aging-related research.

遺傳學特論(一)、(二) (Special Topics on Aging Research I, II)

任課老師：孫孝芳 (選修，各2 學分、開授學期：碩二上、下)

以每學期1-2主題， 藉由個案分析、論文閱讀、專題演講來進行主題科學的教學與討論。

The course is proposed for the students wishing to gain an appreciation of genetics and epigenetics through case report, article presentation and group discussion. In the end of the course, students will be able to catch up the latest scientific breakthroughs and discoveries in the field of genetics and epigenetics, and make a professional presentation and an effective communication.

基因體學與功能生物學(一)、(二) (Genomics and Functional Biology I, II)

           任課老師 : 孫孝芳等(選修，各1學分、開授學期：碩一二上下) -103學年新生適用

人類基因體計畫的執行，疾病與基因的關係因著對基因體功能的瞭解而更加清楚，因此基因體學與功能生物學是應用基因體醫學的基礎，也是現在世界的顯學。

After the Human Genome Project (HGP), the Functional Genomics attempts to make use of the vast wealth of data produced by genomic and transcriptomic projects (such as genome sequencing projects and RNA-seq) to describe gene (and protein) functions and interactions. The objective of this course is to give students basic knowledge of functional genomic on the dynamic aspects such as gene transcription, translation, regulation of gene expression and protein–protein interactions. By the end of the semester, students will be able to explain and give examples of how functional genomic dissect pathogenesis mechanism of human disease in the level of molecular and gene.

遺傳與分子醫學 (Genomics and Molecular Medicine)

任課老師：孫孝芳等(選修，2學分、開授學期：碩一、二上) -103學年新生適用

有系統、一系列的介紹遺傳與分子醫學。

The objectives of the course lead students to understand genetic and molecular medicine through a systematic series of literature. After completing this class, students will be able to illustrate fundamental discoveries in both field of genetic and molecular medicine, and further experience exciting new developments in research and in practical applications.

傳染性疾病與微生物研究導論 (Fundamentals of Infectious Diseases and Microbial Research)

        任課老師：王憲威、鄧景浩等(選修，2學分、開授學期：碩一上)

介紹傳染性疾病概念以及其微生物病原的研究方法，使學生對傳染性疾病以及其致病微生物病原的研究方法有概括性的了解。

This course addresses the general background of infectious diseases and the research principles of pathogenic microorganisms.

微生物致病機轉 (Microbial Pathogenesis)

        任課老師：王憲威、鄧景浩、王貞仁等(選修，2學分、開授學期：碩一、碩二上)

本課程內容主要包括病毒與細菌之致病機轉，分別由基礎及臨床方向探討微生物與宿主之相互關係、致病因子及機制等。對象為曾修習微生物相關課程之碩士或博士生。

This course will cover microbial pathogenesis including viruses, bacteria and parasites. Host-microorganism interactions, virulence factors and mechanisms of microbial pathogenesis will be discussed from basic and clinical point of views. This course is designed for both Master and Ph. D. students who have taken basic microbiology courses.

神經免疫學( Neuroimmunology)-105學年新生適用

任課老師：朱俊憲、孫孝芳等 (選修，2學分 。開授學期：碩一、碩二下)

本課程目標旨在探討腦神經內分泌系統與免疫系統之間的交互作用。課程內容涵蓋腦細胞之基本組成與傳遞機制；進而延伸至神經內分泌和免疫系統以及神經細胞與膠質細胞之間的相互調控。此課程不同於由傳統藥理學或生理學的角度來探討大腦神經的功能，而是由跨學科的角度來探究腦內不同細胞之間與大腦外的免疫系統如何維持正常生理功能和失衡時如何導致疾病發生。事實上，許多人類神經疾病的發生，便是腦內外免疫系統失能所造成，例如：神經退化疾病。透過此一課程，期能培養出具備跨學科視野來探究大腦神經科學的學生。

The objective of the course for students is to introduce neuroendocrine–immune (NEI) circuitry from neuron–glial interactions, brain immunoregulation to their pathophysiological functions in central nervous system (CNS). Students will be able to understand that how brain neurons and glia interact with peripheral endocrine and immune system, in order to maintain physiological homeostasis or progress brain diseases such as neurodegenerative disease.

★分子醫學特論(一)（二）(Special Topics in Molecular Medicine I, II)

任課老師：王憲威、鄧景浩、孫孝芳、橋本昌征 (選修，2學分、開授學期：碩一、碩二上下)

本課程提供博碩士班學生對感染性疾病及癌症研究課題有更深入的了解。每一位授課老師將導引學生深入其研究領域、假說及實驗設計，包含對實驗方法學的批判、資料分析及結果解釋。此課程鼓勵學生參與分醫所授課老師的領域以增強跨領域之訓練與學習。

To inspire and familiarize enrolled IMM students with updated research topics on infectious disease and molecular medicine, which include advanced cancer, viruses, and microbes related researches. IMM students enrolled in this class are encouraged to rotate in different topics for possible interdisciplinary training purpose.

★基礎分子生物學（General Molecular Biology）-108學年新生適用

任課老師：橋本昌征等(選修，3學分、開授學期：碩一上)

將生物現象的種種機能循分子層次進行研究之分子生物學是生物學結合物理學、化學而發展出的新科學領域，隨著分子生物學之進展所開發出之基因工程技術

Molecular biology is an academic discipline to understand complicated biological phenomena at the molecular level. Through the progress of this molecular biology, we have created technologies such as gene therapy and gene recombination. In this lecture, we will learn the fundamentals and applications of molecular biology through the function of genes.

★基礎細胞生物學（General Cell Biology）-108學年新生適用

任課老師：吳梨華(選修，3學分、開授學期：碩一上)

著重於在分子層次探討動物細胞和致病菌之結構、功能和信號傳遞，及細胞增生、分化與死亡的機轉，並介紹傳統與新穎的細胞生物技術。最後，以免疫細胞、神經細胞、寄主與致病菌交互作用、組織再生與癌症的形成，探討這些細胞如何因結構或功能失調而導致人類疾病

Familiarize students with the fundamentals of cell biology and with the application of this knowledge in addressing both basic and clinical research questions. By the end of the course, students would know the basics of fundamental cell biology and how to apply what they learn in addressing cell biology-related questions arising in the research field of their interest, including immunology, neuroscience, microbial pathology, tissue regeneration and cancer biology.

★分子醫學跨學科研究培訓(Interdisciplinary Laboratory Rotation for Molecular Medicine)

任課老師：王憲威 (選修，1學分、開授學期：碩一上) -108學年新生適用

本課程在使外籍學生對最新分子醫學及感染性疾病研究課題能有整體及啟發性的了解，課題包含最新癌症、基因體學、病毒、微生物等相關實驗室之研究及文獻探討。註冊此課程之學生可以經由輪流參與醫學院各實驗室之研究訓練及文獻研讀以達多領域之訓練與學習。除非學生有特殊多實驗室輪替學習需求且經系所所長或指導教授允許，每位學生至多可選擇兩位老師實驗室(可含指導教授)進行輪替之跨領域學習與專業訓練。學生選課前，應諮詢系所所長、指導教授、或時間上可行之指導老師，且必須在第二堂課之前繳交輪替學習之實驗室指導老師名單

To inspire and familiarize enrolled foreign students with updated research topics on molecular medicine and/or infectious diseases, which include advanced oncology, genomics, virology, and/or microbiology related researches in the NCKU Medical College. Students enrolled in this class can rotate in different laboratories for possible interdisciplinary training by participating in relevant bench works and/or journal clubs in specified laboratories. However, unless specific needs for rotation in multiple labs (more than 3 labs) were requested for the student by the department chair or tentative advisor of the student, each student is allowed to select two instructors at most per semester for such interdisciplinary training (note that advisor can be included in the list). Students must consult their departmental chair, advisors, and/or available instructors before taking this course, and a list of favorable instructors for the rotation must hand in to the course coordinator before the 2nd class begins.

★現代生物技術（Modern Biotechnology）-108學年新生適用

任課老師：橋本昌征等(選修，1學分、開授學期：碩一上)

醫學檢驗及生物技術都是日新月異、一日千里的科技科學。除了學理知識時刻在更新外，應用的儀器或設備也時時翻新。生醫相關技術及儀器訓練是培養醫學檢驗、醫學研究及生物科技專業研發及產業人才的必須課程

Medical tests and biotechnology are science and technology that constantly change almost everyday. In addition to the updating of academic knowledge, the applied instruments or equipment are continuously renovated. Biomedical related technologies and instrument training are essential courses for training students for the medical testing, medical research and biotechnology professions. Students will also be exposed to current biotechnology and pharmaceutical developments or job opportunities in Taiwan and Asia. English is used in the classroom and in written reports.

★人工智慧對神經科學之應用(Introduction to artificial intelligence for neuroscience )

任課老師：朱俊憲、徐褘祐等 (選修，3學分 。開授學期：碩博下) -112學年新生適用

本課程從跨領域的視角來簡介人工智能技術在神經科學研究中的應用。將向學生傳授人工智能的知識和概念、各種人工智能流程/技術，包括深度學習框架以及基礎神經科學。通過實踐經驗，他們將逐步掌握構建、訓練和評估深度神經網絡模型的藝術及其在神經影像分析中的應用。使得學生能掌握使用人工智能進行神經影像分析所需的基本技能

This course provides an interdisciplinary perspective on the introduction and application of artificial intelligence (AI) technology to neuroscience research. The knowledge and concept of AI, various AI processes/techniques, including deep learning frameworks, and basic neuroscience will be delivered to students. Through hands-on experience, they will master the art of constructing, training and evaluating deep neural network models step by step and their application in neuroimaging analysis. The curriculum is structured to equip students with the essential skills needed for neuroimaging analysis using AI.

論文 (Thesis)

任課老師：張南山、孫孝芳、吳梨華、蔣輯武、王憲威、鄧景浩、張定宗、蘇五洲、周楠華、何中良、陳立宗、林世杰、朱俊憲、劉紋君、孫宏羽….等(必修、6學、開授學期：碩二下)

指導學生之研究成果發表。

Instruct students to publish research results.